| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Derivation of toxicity equivalency factors for marine biotoxins associated with Bivalve Molluscs
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| Autores: |
Botana, Luis M.
Hess, Philipp
Munday, Rex
Nathalie, Arnich
Degrasse, Stacey L.
Feeley, Mark
Suzuki, Toshiyuki
Van Den Berg, Martin
Fattori, Vittorio
Gamarro, Esther Garrido
Tritscher, Angelika
Nakagawa, Rei
Karunasagar, Iddya
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| Data: |
2017-01
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| Ano: |
2017
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| Palavras-chave: |
Marine toxins
Toxicity Equivalency Factors
FAO
WHO
Bivalve
Mollusc
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| Resumo: |
Background Seafood toxins pose an important risk to human health, and maximum levels were imposed by regulatory authorities throughout the world. Several toxin groups are known, each one with many analogues of the major toxin. Regulatory limits are set to ensure that commercially available seafood is not contaminated with unsafe levels. Scope and Approach The mouse bioassay was used to measure the toxicity in seafood extracts to determine if a sample exceeded regulatory limits. The advantage of this approach was to provide an estimation of the total toxicity in the sample. As instrumental methods of analysis advance and serve as replacements to the mouse bioassay, the challenge is translating individual toxin concentrations into toxicity to determine whether regulatory limits have been exceeded. Such analyses provide accurate quantitation of the toxin analogues, by they have widely dissimilar potencies. Thus, knowledge of the relative toxicities is required for risk assessment and determining overall toxicity. The ratios between the toxicity of the analogues and that of a reference compound within the same toxin group are termed “Toxicity Equivalency Factors” (TEFs). Key Findings and Conclusions: In this document, the requirements for determining TEFs of toxin analogues are described, and recommendations for research to further refine TEFs are identified. The proposed TEFs herein, when applied to toxin analogue concentrations determined using analytical methods, will provide a base to determine overall toxicity, thereby protecting human health.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00358/46960/46874.pdf
DOI:10.1016/j.tifs.2016.09.015
http://archimer.ifremer.fr/doc/00358/46960/
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| Editor: |
Elsevier Science London
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| Formato: |
application/pdf
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| Fonte: |
Trends In Food Science & Technology (0924-2244) (Elsevier Science London), 2017-01 , Vol. 59 , P. 15-24
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| Direitos: |
2016 Published by Elsevier Ltd.
info:eu-repo/semantics/openAccess
restricted use
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